Growth factor regulation of growth factor production by multiple gene transfer to chondrocytes
نویسندگان
چکیده
منابع مشابه
Vascular Endothelial Growth Factor Production is Regulated by Gene Polymorphisms
Background: Vascular endothelial growth factor (VEGF) has a key role in angiogene-sis and in transplantation. The level of VEGF is related to the differences in the DNA sequence of its promoter region. Objectives: In this study, the association between the combination of VEGF –1154 G and –2578 C alleles and VEGF production by LPS-stimulated PBMCs was investigated. In addition; the relationship ...
متن کاملvascular endothelial growth factor production is regulated by gene polymorphisms
background: vascular endothelial growth factor (vegf) has a key role in angiogene-sis and in transplantation. the level of vegf is related to the differences in the dna sequence of its promoter region. objectives: in this study, the association between the combination of vegf –1154 g and –2578 c alleles and vegf production by lps-stimulated pbmcs was investigated. in addition; the relationship ...
متن کاملRegulation of estrogen receptor- gene expression by epidermal growth factor
The role of epidermal growth factor (EGF) in the regulation of estrogen receptor(ER) gene expression in the human breast cancer cell line MCF-7 was investigated. Treatment of cells with 0·4 ng/ml EGF resulted in an approximately 60% decrease in ERprotein concentration by 6 h and the amount of receptor remained suppressed for 24 h. Ligand binding assays demonstrated that the decrease in ERprotei...
متن کاملHierarchical model of gene regulation by transforming growth factor beta.
Transforming growth factor betas (TGF-betas) regulate key aspects of embryonic development and major human diseases. Although Smad2, Smad3, and extracellular signal-regulated kinase (ERK) mitogen-activated protein kinases (MAPKs) have been proposed as key mediators in TGF-beta signaling, their functional specificities and interactivity in controlling transcriptional programs in different cell t...
متن کاملRegulation of corneal repair by particle-mediated gene transfer of opioid growth factor receptor complementary DNA.
OBJECTIVE To determine whether molecular manipulation of the opioid growth factor receptor (OGFr) alters corneal reepithelialization following central corneal abrasion in rats. METHODS The plasmid pcDNA3.1 + OGFr, carrying the rat OGFr complementary DNA in both the sense and antisense orientations, and empty vector (EV), were delivered by gene gun to the rat cornea. After 24 hours, corneas we...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Growth Factors
سال: 2013
ISSN: 0897-7194,1029-2292
DOI: 10.3109/08977194.2012.750652